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Liraglutide has 97% homology with human GLP-1 with a half-life of over 13 hours [23]
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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity — either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) — on alcohol consumption in both humans and preclinical models (Figure 1) (4)
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