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Use Cases Explored Clinical trial protocols studying weight management in adults with obesity or overweight Clinical trial protocols studying glycemic control in adults with type 2 diabetes and obesity Clinical trial protocols studying cardiovascular risk-factor reduction Clinical trial protocols studying knee osteoarthritis pain in patients with obesity The Evidence TRIUMPH-1 (Phase 3, reported May 2026) Participants on the 12 mg dose lost an average of 28.3% of body weight at 80 weeks, with 45.3% of participants reaching 30% or greater weight loss — a magnitude historically associated with bariatric surgery

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Minimize temperature excursions Take your tirzepatide out of the refrigerator only when you are ready to inject