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Protein Before Noon for GLP-1 Weight Loss | David Propst posted on the topic | LinkedIn
The primary competitive concern is whether its modest incremental weight loss advantage over tirzepatide (the current standard) justifies its differentiated side effect profile, particularly if glucagon agonism increases bone turnover, hepatic glucose production at higher doses, or cardiovascular risk
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β-Arrestin Recruitment: Following G-protein coupling, GLP-1R is phosphorylated by G-protein-coupled receptor kinases (GRKs), leading to β-arrestin recruitment
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