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GLP-1 Receptor Agonists: What They Do & Who Can Use Them – Bolt Pharmacy
Interestingly, the mean values remain relatively normal in most T2DM groups (31–33), suggesting that the impaired incretin releases are not a typical prerequisite for the development of T2DM
In another study, semaglutide exhibited greater potency in activating GLP-1R compared to GLP-1, with an EC50 of 6.2 pM for semaglutide vs 16.2 pM for GLP-1 (95) (The variability in EC50 values among different studies for GLP-1 was not uncommon attributable to varying assay conditions)
