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The sponsor conducted several scenario analyses on each modelled population, including taking a taking a societal perspective, omitting discounting, increasing the discount rate to 3%, using a 20-year time horizon, changing the threshold for intensification treatment to 8.5% from 8%, and using the number of years associated with the initial treatment as opposed to using hemoglobin A1C as a threshold for intensification (i.e., the intensification trigger threshold was 4 years for second-line treatment and 5 years for third-line treatment)
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