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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex | Nature

In humans, GLP1 and GLP1 analogues have been shown to be beneficial for the treatment of chronic inflammatory diseases, such as non-alcoholic fatty liver disease, atherosclerosis and neurodegenerative disorders 100,101 and these effects seem to be primarily mediated by a reduction in the activity of inflammatory pathways 91

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it is frequently comorbid with hypertension, dyslipidemia, fatty liver disease, and sleep apnea