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In contrast to previous studies, the incidence of bowel obstruction (including ileus, intussusception, volvulus, neurogenic bowel, megacolon, and other types of bowel obstruction) was not found to differ between SGLT-2 inhibitors and GLP-1RAs but tended to be nonsignificantly protective against these diagnoses (adjusted HR 0.83 [95% CI 0.69 to 1.01])
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How They May Support Weight Management GLP-1 contributes to satiety signaling, but whether a specific supplement meaningfully improves this pathway depends on its ingredients, dose, and evidence from human studies
