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Mice lacking OL GIPR showed reduced energy expenditure and intake, preserved oral glucose tolerance, impaired insulin tolerance, and shifts in branched-chain–related metabolites, consistent with altered substrate handling during obesity
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Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide (Ozempic), have emerged as effective treatments for weight management and type 2 diabetes by enhancing insulin secretion, suppressing appetite, and slowing gastric emptying
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