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Although TRT is widely accepted, it is not without drawbacks—complications such as erythrocytosis, worsening of obstructive sleep apnea, and increased cardiovascular risk have been reported [1]
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But at the time the company was considering the trial, Peter Johannsen, international medical vice president of Novo Nordisk, told Being Patient that blood biomarkers weren’t developed to the extent where they could be used to screen for people at-risk while cognitively healthy and would require PET scans or lumbar punctures, making a large study difficult to run
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