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Retatrutide Dosing Based on Phase 2 trial protocols and emerging Phase 3 data, Retatrutide dosing follows a structured escalation pattern: Starting dose: 0.5mg to 1mg weekly Escalation: Increase every 4 weeks in increments Intermediate doses: 2mg, 4mg, 8mg Maximum dose: 12mg weekly Time to maximum: Approximately 20-24 weeks The commercial formulation, once approved, will likely include pre-filled injection pens similar to those used for semaglutide and tirzepatide

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Sanyal ESSENCE is an ongoing phase 3 randomized controlled trial that enrolled 1,197 adults aged 18 years and older with histologically diagnosed steatohepatitis, stage 2 or 3 liver fibrosis and a nonalcoholic fatty liver disease (NAFLD) activity score of 4 or higher