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According to Leerink analyst David Reisinger, retatrutide showed higher gastrointestinal side effects than Zepbound, “as expected,” plus “much higher rates of dysesthesia.” William Blair’s Andy Shea acknowledged that the placebo-adjusted weight loss “compares favourably to the 18% figure for Zepbound” but predicted the drug “will likely be limited to individuals at the higher end of the BMI spectrum.” In plain terms: retatrutide works spectacularly, but it’s probably too punishing for routine use
