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In the majority of the trials, the primary composite CV endpoint was a three-component major adverse CV event (MACE) outcome including CV-related mortality, non-fatal myocardial infarction (MI), and non-fatal stroke (the CVOT investigating lixisenatide, the ELIXA trial, also included time to the first occurrence of hospitalisation for unstable angina pectoris)
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When levels dip, even slightly, you can start to feel unwell very quickly