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Pre-filled pens for tirzepatide and semaglutide need refrigeration (2–8 °C) until first use, and even after first use most stay stable at room temperature only for a limited window — UK SmPCs allow up to 30 days at no more than 30 °C for an in-use Mounjaro KwikPen, up to 56 days for an in-use Ozempic pen, and up to 28 days unrefrigerated for a Wegovy pre-filled pen
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Ozempic is also approved to help reduce the risk of heart attack and stroke in adults with diabetes and heart disease, as well as lower the risk of kidney-related problems for adults with diabetes and chronic kidney disease
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